Cancer takes a one-two punch in Charleston this weekend with a couple of events that raise a chunk of change to fight the disease.

Race for the Cure

The Komen Lowcountry Race for the Cure celebrates its 20th year Saturday at Family Circle Magazine Stadium on Daniel Island.

The first event was dramatically different from the mega events of the past decade. In 1994, the first event was for women only, drew 612 finishers and was held in downtown Charleston.

Last year, 9,300 men, women and children registered for the event and a record 5,376 finished the 5K in the first year that the affiliate timed participants.

That finisher record will likely stand as the affiliate has reinstated the option not to be timed. As a result, those who opt not to be timed won’t be counted as an official finisher.

According to Komen Lowcountry’s website, its goals this year is to have 12,000 registrants and to raise $1 million.

Saturday’s event basically runs from 7-11 a.m., with the expo starting at 7 a.m., the survivor ceremony at 8 a.m., the one-mile fun run and walk at 8:30 a.m., the 5K at 9:15 a.m. and the awards ceremony at 10 a.m.

Late registration is $45 for the 5K and fun run, or $35 to “Sleep in for the Cure.” Packet pick-up and late registration is 9 a.m.-6 p.m. Friday and starting at 7 a.m. Saturday at Family Circle.

Due to extreme traffic congestion in the past, organizers urge participants to carpool or to use a free shuttle service starting at 6:30 a.m. from the CARTA parking lot at 3621 W. Montague in North Charleston or at the Mount Pleasant Towne Centre.

Zucker Ride for Hope

While 10,000-plus will help Komen try to reach $1 million, one fundraiser with 1.5 percent of those participants likely will raise $100,000.

The Jerry Zucker Ride for Hope has raised and donated more than $500,000 to local cancer causes in the past five years. The sixth annual ride, which features a metric century and several shorter rides Sunday, is staged from Awendaw Green in Awendaw.

The 100K starts at 8 a.m., a 30-miler at 9 a.m. and a 10-miler at 10:30 a.m. Lunch will be 11 a.m.-2 p.m. when the band Hit or Miss, which features Joel Timmons and Ward Buckheister of Sol Driven Train, is scheduled to play.

While one of the reasons this relatively small fundraiser, from a participant standpoint, raises so much money is the required minimum of $500 raised per rider. That said, this is the first year the event is offering the 10-mile “Cruiser Ride” (appropriate for beginners and families) for a minimum of $250.

One of the draws to the Zucker Ride for Hope is a chance for people to ride with Tour de France veteran George Hincapie, who has helped lure riders by posting it on his Twitter account (with 136,852 followers as of Monday).

“George has been great,” says Zucker Ride founder and Director Dawson Cherry, noting that Hincapie has donated six slots to his Gran Fondo ride on Oct. 26 in Greenville.

U.S. 17 road trips

Another ride and run, set for Saturday and Sunday, respectively, are being held a ways down U.S. Highway 17.

The Yemassee Revitalization Corporation will be hosting the organization’s fifth annual Prince William Cycle Tour at Buckfield Plantation in Yemassee on Saturday.

The 22nd Hargray Hilton Head Island Bridge Run, a 10K and 5K, begins at 8 a.m. Sunday, starting and finishing at Crossings Park.

In Yemassee, the bicycling event will feature a 67-mile ride and a 34-mile ride. Both tours explores the scenic country roads of Beaufort, Jasper and Hampton counties. The cost is $35 Thursday and Friday, and $45 Saturday. All proceeds go to the Yemassee Revitalization Corporation.

The Hilton Head Island Bridge Run will take participants over the Broad Creek Bridge and up the Cross Island Parkway. The fee is $35 and proceeds benefit Area 8 Special Olympics and The Children’s Relief Fund.

To the streets

Finally, a 5K run will be held at 9 a.m. Saturday at the North Charleston High School football field as part of the fall festival to benefit Take It To The Streets, which is working to raise awareness about the needs of students and families in local neighborhoods in North Charleston.

The run registration is $25 and the fall festival is $5.